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However, clinical experience with Lariam has not revealed an embryotoxic or teratogenic effect. The benefits of Lariam therapy should be weighed against the possibility of adverse effects in patients with cardiac disease. If these drugs are to be used in the initial treatment of severe malaria, Lariam administration should be delayed at least 12 hours after the last dose. Women of childbearing potential should also be advised to practice contraception during malaria prophylaxis with Lariam and for up to 3 months thereafter. One 250 mg Lariam tablet should be taken once weekly in pediatric patients weighing over 45 kg. Because these experiences are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to Lariam exposure.

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